Molecular NeuroBiology lab @ KBRI

Dissecting Learning and Memory!

optogenetics

Exploring working mechanisms for working memory

PPC-PFC
Sustained neural activity in the cortex is thought to be the cellular mechanism of working-/short-term memory, but underlying mechanisms is still unclear. By focusing on the PPC-PFC circuit and utilizing several innovative molecular / viral vector tools, imaging, and slice physiology techniques, we would like to identify behaviorally-relevant PPC-PFC synapses and study their role in decision making behaviors.

You can see more if you have a tool.



tag system
Despite many available tools labeling specific types of cells and circuits for identifying behaviorally-relevant neural connectivity, neurobiologists are still eager to develop fine molecular tools for simultaneous labeling and manipulation of multiple cells/circuits, because multiple cells/circuits are concurrently involved in the simple brain function. By developing new viral vectors for selectively manipulating multiple gene expression in vivo, we aim to provide efficient genetic tools ideal for studying complex neural circuits regulating learning and memory.


Another "star" player in the field: astrocyte

model1


Proper regulation of neural circuit formation/elimination & plasticity is essential for normal cognitive functions including learning and memory. We are focusing on the role of glia cells, astrocytes, in regulating "neural synapses" in functional and structural levels. In addition, we are also interested in identifying novel molecular factors mediating neuron-glia interaction, which is involved in long-term synaptic plasticity and learning & memory processes.