Based on basic findings about molecular mechanisms regulating normal cognitive functions, we aim to explore key mechanisms related with neurodegenerative diseases. By identifying certain mechanisms altered in the diseased circuits when compared to neuro-glia interactions in the normal neural circuits, our study will provide basic ideas for better diagnosing tools or treatments.

Tags: neuroglia interaction, astrocyte, synapse, synaptic plasticity, gliotransmitter, BDNF, synapse pruning, neurodegenerative disease, ad, pd, hd, slice physiology